Medications are available that can reduce chances of severe illness and death from COVID-19. The FDA issued emergency use authorizations for certain antiviral medications and monoclonal antibodies to treat mild to moderate COVID-19 in people who are more likely to get sick. NIH also provides COVID-19 treatment guidelines for healthcare providers for home use or in an outpatient setting. This webinar provides COVID-19 therapeutic options, including indications, efficacy, and distribution.